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KMID : 0352719870110020203
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Journal of Ginseng Research
1987 Volume.11 No. 2 p.203 ~ p.210
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Psychotropic Effects of Ginseng Saponins on Agonistic Behavior in Male and Female Mice
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Yoshimura, Hiroyuki
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Abstract
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Psychotropic actions of crude ginseng saponins(CGS), pure ginsenosiue Rbl(GS-bl) and ginsenoside Rgl(GS-gl) isolated from the root of Pan= ginseng, were evaluated by determining their effects on agonistic behavior in male(Experiment 1) and female(Experiment 2) mice, using a biologically relevant method. The results of experiment 1 demonstrated that CGS and GS-bl significantly suppressed aggressive episodes(offensive sideways posture and attack bite) in a dose-dependent manner when the resident was drugged, whereas GS-gl was ineffective. However, when the intruder was treated with one of three ginseng saponins, agonistic behavior between resident and intruder males was not altered. In experiment 2, acute administration of CGS and GS-bl significantly suppressed maternal aggression, whereas GS-gl was ineffective. As compared with the vehicle-treated group, chronic treatment with CGS and GS-bl significantly suppressed maternal aggression, while GS-gl showed a tendency to increase the frequency of attack bite by females. These findings clearly indicate that the root of Pan= ginseng contains psychoactive ingredient which can suppress both intermale and maternal aggression in mice. We suggest that the present results have important implications for the clinical usefulness of ginseng saponins in psychiatric medicine.
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